By: Zhou, Fangjun ; Shefer, Abigail ; Wenger, Jay
Researchers performed decision analysis using population-based vaccination coverage, published vaccine efficacies, historical data on disease incidence before vaccination, and disease incidence reported from 2005 to 2009 to determine the economic impact of the 2009 routine U.S. childhood immunization schedule. They considered costs related to the vaccine, administration, vaccine-associated adverse events, and parent travel time and work time lost, inflated to 2009 dollars and discounting all future costs and benefits at a 3 percent annual rate. Then, they followed a hypothetical 2009 U.S. birth cohort of 4.2 million infants from birth through death to calculate net present value and benefit-cost ratios of routine childhood immunization. Among this cohort, they determined that routine childhood immunization will prevent 20 million cases of disease and 42,000 early deaths, as well as save a net $13.5 billion in direct costs and $68.8 billion in societal costs.
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