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Immunization Science

NNii provides up-to-date information on immunization science. This section contains synopses of articles from the scientific, peer-reviewed literature related to vaccines and immunization. Each synopsis includes a comment from NNii intended to guide readers on the strengths, weaknesses and implications of the study.


Pneumococcal Vaccine (10 Articles)

  • PPV23 and Adults with Pneumonia

    This study evaluates whether prior immunization with the 23-valent pneumococcal polysaccharide vaccine improves clinical outcomes among adult patients hospitalized with community-acquired pneumonia.
  • PCV7 Adverse Events

    This study identified the types of adverse events reported to the Vaccine Adverse Events Reporting System after vaccination with the 7-valent pneumococcal vaccine (PCV7) and assesed those that warranted further investigation.
  • PCV7 and Invasive Pneumococcal Disease

    This study shows that the recommendation for universal PCV7 vaccination has resulted in a decline of childhood invasive pneumococcal disease in Massachusetts.
  • Effectiveness of Pneumococcal Vaccines in Adults

    This study reviews the effectiveness of PPS-23 vaccines in preventing invasive pneumococcal disease and pneumonia from all causes among adults more than 65 years of age or with chronic health problems.
  • PCV7 and Ear Infections

    A number of bacteria cause ear infections in children. Some of these children require a surgical procedure called tympanostomy tube placement. This study shows that the PCV7 immunization reduced the number of these surgeries.
  • PCV7 and Antibiotic Resistance

    PCV7 vaccination of young children has resulted not only in lower rates of invasive pneumococcal disease but also a lower proportion of strains which are resistant to antibiotic in children less than as well as in persons older than 2 years of age.
  • Elimination of Racial Differences in Pneumococcal Disease

    This study shows that introduction of the conjugate pneumococcal vaccine reduced the incidence of invasive pneumococcal disease and eliminated racial differences in the incidence rates of the disease in young children in Tennessee.
  • Impact of a large PCV7 Vaccination Program

    This study shows the effect of the vaccination program for young children against pneumococcal disease in the population of a large HMO: decrease in the incidence of the disease and decrease in antibiotic-resistant pneumococci.
  • Pneumococcal Vaccine and Racial Disparities

    In the past, the incidence of invasive pneumococcal disease has been higher among blacks than among whites in the United States. Pneumococcal vaccine has reduced this disparity.
  • How effective is PCV7?

    This study shows that pneumococcal vaccine (PCV7) has been effective in decreasing pneumococcal infections, which cause ear infections, sinus infections, pneumonia requiring hospitalization, and bacterial meningitis.
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