Effects of the Live Attenuated Measles-Mumps-Rubella Booster Vaccination on Disease Activity in Patients With Juvenile Idiopathic Arthritis

Source: Journal of the American Medical Association | Vol:Vol. 309 | Page: 2449

By: Heijstek, Marloes W. ; Kamphuis, Sylvia ; Ambrust, Wineke


Researchers studied 137 children with juvenile idiopathic arthritis (JIA) at five academic hospitals in the Netherlands from May 2008 to July 2011 to determine whether the MMR booster vaccine affects disease activity. The patients were all between the ages of four and nine years. The researchers found no difference in disease activity between the 63 patients who received the booster and the 68 controls who did not. However, at 12 months, they found that the revaccinated patients had higher seroprotection rates and higher antibody concentrations against measles than the control group. The authors concluded that the MMR booster vaccine did not worsen JIA disease activity, but they said larger studies must be conducted to gauge the impact of the MMR booster on patients taking biologics.

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