Intussusception After Rotavirus Vaccines Reported to US VAERS, 2006-2012

Source: Pediatrics

By: Haber, Penina ; Patel, Manish ; Pan, Yi


Researchers identified 584 confirmed intussusception events reported to the Vaccine Adverse Event Reporting System after the RotaTeq (RV5) vaccine and 52 such events after the Rotarix (RV1) vaccine from their introduction in February 2006 and April 2008, respectively, through April 2012. Clustering was observed three to six days after both rotavirus vaccines, but the researchers found no significant increase in reporting following the second and third doses. They concluded that the excess risk of intussusception for all three doses was 0.79 events per 100,000 vaccinations, and they stress that the benefits of rotavirus vaccination outweigh the small increased risk of intussusception.

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