Immunogenicity of 2 Doses of HPV Vaccine in Younger Adolescents vs 3 Doses in Young Women

Source: Journal of the American Medical Association

By: Dobson, Simon R. M. ; McNeil, Shelly ; Dionne, Marck


Researchers studied 830 Canadian females from August 2007 to February 2011 to compare antibody levels to HPV-16 and HPV-18 among girls receiving two doses and women receiving three doses, with 675 participants providing follow-up blood samples. They determined that for girls ages 9 to 13 who received two doses of the HPV vaccine six months apart, their responses one month after the last dose were noninferior to women ages 16 to 26 who received three doses with six months. There was some loss of noninferiority to some genotypes at 24 to 36 months after the last dose in girls who received two doses compared to those who received three doses, so researchers indicate that more data is needed before reduced-dose schedules can be suggested.

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