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Association Between Guillain-Barre Syndrome and Influenza A (H1N1) 2009 Monovalent Inactivated Vaccines in the USA: A Meta-Analysis

Source: The Lancet

By: Salmon, Daniel A. ; Proschan, Michael ; Forshee, Richard

03/13/2013

Researchers performed a meta-analysis of data from six adverse event monitoring systems covering around 23 million vaccinated individuals to determine whether the influenza A (H1N1) monovalent inactive vaccine involved in the 2009 mass vaccination initiative in the United States increased the risk of Guillain-Barre syndrome. They identified a small increased risk of Guillain-Barre syndrome, amounting to about 1.6 excess cases per million people vaccinated. The researchers concluded that the benefits of inactivated pandemic vaccines outweigh the risks.



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